The Receptor for the Orexigenic Peptide Melanin-concentrating Hormone is a G-protein-coupled Receptor

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 1999 Nov 13

PMID 10559938

Citations 71

Authors

P M Lembo

E Grazzini

J Cao

D A Hubatsch

M Pelletier

C Hoffert

C Pou

J Labrecque

T Groblewski

D ODonnell

K Payza

S Ahmad

P Walker

Affiliations

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Abstract

Gene-knockout studies of melanin-concentrating hormone (MCH) and its effect on feeding and energy balance have firmly established MCH as an orexigenic (appetite-stimulating) peptide hormone. Here we identify MCH as the ligand for the orphan receptor SLC-1. The rat SLC-1 is activated by nanomolar concentrations of MCH and is coupled to the G protein G alpha i/o. The pattern of SLC-1 messenger RNA expression coincides with the distribution of MCH-containing nerve terminals and is consistent with the known central effects of MCH. Our identification of an MCH receptor could have implications for the development of new anti-obesity therapies.

Citing Articles

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Guo B, Zhu Y, Lu S, Chen X, Ren Z, Liu Y Adv Sci (Weinh). 2024; 11(43):e2309951.

PMID: 39320347 PMC: 11578307. DOI: 10.1002/advs.202309951.

Regulation of the Mouse Ventral Tegmental Area by Melanin-Concentrating Hormone.

Spencer C, Miller P, Williams-Ikhenoba J, Nikolova R, Chee M J Neurosci. 2024; 44(27).

PMID: 38806249 PMC: 11223476. DOI: 10.1523/JNEUROSCI.0790-23.2024.

Hypothalamic MCH Neurons: From Feeding to Cognitive Control.

Concetti C, Peleg-Raibstein D, Burdakov D Function (Oxf). 2023; 5(1):zqad059.

PMID: 38020069 PMC: 10667013. DOI: 10.1093/function/zqad059.

An anatomically distinct subpopulation of orexin neurons project from the lateral hypothalamus to the olfactory bulb.

Qi M, Fadool D, Storace D J Comp Neurol. 2023; 531(15):1510-1524.

PMID: 37434469 PMC: 10758201. DOI: 10.1002/cne.25518.

Fast neurotransmitter identity of MCH neurons: Do contents depend on context?.

Beekly B, Rupp A, Burgess C, Elias C Front Neuroendocrinol. 2023; 70:101069.

PMID: 37149229 PMC: 11190671. DOI: 10.1016/j.yfrne.2023.101069.