Gut Intraepithelial Lymphocytes and Immunity to Coccidia

Overview

Journal Parasitol Today

Specialty Parasitology

Date 1999 Nov 11

PMID 10557148

Citations 6

Authors

V McDonald

Affiliations

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Abstract

Little is known about the physiological functions of the intra-epithelial lymphocytes (IELs) of mucosal tissues, including their role in immunity to infection. Most IELs are T cells, but their surface phenotype and activation characteristics are different from those of peripheral T cells. Here, Vincent McDonald outlines the distinctive features of IELs and presents evidence, particularly from studies of Coccidia, that these cells have an important role in the control of intracellular infection at the mucosal surface.

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