Article: [Relevance of the radioprotective effect of sodium selenite]

Material And Method: Based on the mode of action of Na2SeO3 as a radical scavenger in vitro culture experiments using normal human skin fibroblasts and squamous cell carcinoma cells were performed to investigate the potential role of Na2SeO3 as a radioprotector for normal cells. Therefore, comparative studies of combined treatment, i.e. radiation exposure +/- Na2SeO3 in single-dose (0 to 7 Gy) and multiple fractionated-dose (5 x 2 Gy), were applied to differentiate the radiation response of normal and tumor cells depending upon the treatment protocol.

Results: The results indicate that Na2SeO3 under both radiation exposure conditions positively modulates the radiation response of normal fibroblasts in a sense of the radioprotective effect. On the contrary, human tumor cells are not affected by the radioprotective capacity of Na2SeO3 neither under single-dose nor fractionated-dose irradiation.

Conclusion: On the basis of the quantitative cell culture analyses, this study indicates for the first time the potential role of Na2SeO3 as a radioprotective compound for normal cells. It will be discussed to what degree differential expression of apoptotic cell death in normal and tumor cells contributes to the radiation response of normal and tumor cells.

Citing Articles

A Plea for Monitoring Serum Selenium Levels in Breast Cancer Patients: Selenium Deficiency Is Rare during the First Year of Therapy, and Selenium Supplementation Is Associated with Elevated Risk of Overdosing.

Altmayer L, Lang M, Schleicher J, Stuhlert C, Wormann C, Scherer L Nutrients. 2024; 16(13).

PMID: 38999881 PMC: 11243168. DOI: 10.3390/nu16132134.

Effect of Selenium on Incidence and Severity of Mucositis during Radiotherapy in Patients with Head and Neck Cancer.

Laali E, Manifar S, Kazemian A, Jahangard-Rafsanjani Z, Gholami K Oral Health Prev Dent. 2020; 18(4):765-771.

PMID: 32895660 PMC: 11654496. DOI: 10.3290/j.ohpd.a45080.

Selenium does not affect radiosensitivity of breast cancer cell lines.

Schilling D, Herold B, Combs S, Schmid T Radiat Environ Biophys. 2019; 58(3):433-438.

PMID: 31201502 DOI: 10.1007/s00411-019-00801-5.

Selenium in Radiation Oncology-15 Years of Experiences in Germany.

Muecke R, Micke O, Schomburg L, Buentzel J, Kisters K, Adamietz I Nutrients. 2018; 10(4).

PMID: 29652817 PMC: 5946268. DOI: 10.3390/nu10040483.

Protective effects of sodium selenite supplementation against irradiation-induced damage in non-cancerous human esophageal cells.

Puspitasari I, Yamazaki C, Abdulah R, Putri M, Kameo S, Nakano T Oncol Lett. 2017; 13(1):449-454.

PMID: 28123581 PMC: 5244832. DOI: 10.3892/ol.2016.5434.

References

1.

Combs Jr G, Gray W . Chemopreventive agents: selenium. Pharmacol Ther. 1998; 79(3):179-92. DOI: 10.1016/s0163-7258(98)00014-x. View

2.

Dittmann K, Gueven N, Mayer C, Ohneseit P, Zell R, BEGG A . The presence of wild-type TP53 is necessary for the radioprotective effect of the Bowman-Birk proteinase inhibitor in normal fibroblasts. Radiat Res. 1998; 150(6):648-55. View

3.

Rodemann H, Bayreuther K, Francz P, Dittmann K, Albiez M . Selective enrichment and biochemical characterization of seven human skin fibroblasts cell types in vitro. Exp Cell Res. 1989; 180(1):84-93. DOI: 10.1016/0014-4827(89)90214-0. View

4.

Zhu Z, Kimura M, Itokawa Y, Aoki T, Takahashi J, Nakatsu S . Apoptosis induced by selenium in human glioma cell lines. Biol Trace Elem Res. 1996; 54(2):123-34. DOI: 10.1007/BF02786259. View

5.

Herskind C, Bentzen S, Overgaard J, Overgaard M, Bamberg M, Rodemann H . Differentiation state of skin fibroblast cultures versus risk of subcutaneous fibrosis after radiotherapy. Radiother Oncol. 1998; 47(3):263-9. DOI: 10.1016/s0167-8140(98)00018-8. View

[Relevance of the Radioprotective Effect of Sodium Selenite]