DNA Wrapping in Transcription Initiation by RNA Polymerase II

Overview

Journal Biochem Cell Biol

Specialties Biochemistry
Cell Biology

Date 1999 Nov 5

PMID 10546889

Citations 3

Authors

B Coulombe

Affiliations

Soon will be listed here.

Abstract

The DNA wrapping model of transcription stipulates that DNA bending and wrapping around RNA polymerase causes an unwinding of the DNA helix at the enzyme catalytic center that stimulates strand separation prior to initiation and during transcript elongation. Recent experiments with mammalian RNA polymerase II indicate the significance of DNA bending and wrapping in transcriptional mechanisms. These findings have important implications in our understanding of the role of the general transcription factors in transcriptional initiation and the mechanisms underlying transcriptional regulation.

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