A New Bisabolene Epoxide from Tussilago Farfara, and Inhibition of Nitric Oxide Synthesis in LPS-activated Macrophages

Overview

Journal J Nat Prod

Date 1999 Nov 2

PMID 10543912

Citations 2

Authors

J H Ryu

Y S Jeong

D H Sohn

Affiliations

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Abstract

A new bisabolene epoxide was isolated from the flower buds of Tussilago farfara, and the structure was determined by spectroscopic methods to be 1alpha,5alpha-bisacetoxy-8-angeloyloxy-3beta, 4beta-epoxy-bisabola-7(14),10-dien-2-one (1). Compound 1 showed inhibition of nitric oxide synthesis in lipopolysaccharide-activated macrophages.

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