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A 'natural' Mutation in Saccharomyces Cerevisiae Strains Derived from S288c Affects the Complex Regulatory Gene HAP1 (CYP1)

Overview
Journal Curr Genet
Specialty Genetics
Date 1999 Dec 14
PMID 10541856
Citations 82
Authors
M Gaisne
A M Becam
J Verdiere
C J Herbert
Affiliations
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Abstract

The HAP1 gene encodes a complex transcriptional regulator of many genes involved in electron-transfer reactions and is essential in anaerobic or heme-depleted conditions. We show here that strains derived from S288c carry a defective Ty1 element inserted in the 3' region of the HAP1 ORF. This mutant allele acts as a HAP1 null allele in terms of cytochrome c expression and CYC1 UAS1-dependent transcription, but is able to sustain limited growth in heme-depleted conditions.

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