Urease-based Mucosal Immunization Against Helicobacter Heilmannii Infection Induces Corpus Atrophy in Mice

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1999 Oct 26

PMID 10531292

Citations 10

Authors

C Dieterich

H Bouzourene

A L Blum

I E Corthesy-Theulaz

Affiliations

Soon will be listed here.

Abstract

Mucosal immunization with Helicobacter heilmannii urease B or Helicobacter pylori urease, given nasally with cholera toxin, protects BALB/c mice against H. heilmannii infection and significantly reduces a preexisting infection. However, immunization aggravates gastric corpus atrophy. Our results underline the necessity of defining immunization regimens that do not enhance mucosal damage.

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