Myosin Structure: Does the Tail Wag the Dog?

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 1999 Oct 26

PMID 10531021

Citations 3

Authors

R Cooke

Affiliations

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Abstract

Previous crystal structures of the myosin head have shown two different conformations, postulated to be the beginning and the end of the actomyosin power stroke. A new crystal structure reveals a dramatically different conformation; but how does this conformation fit into the force-generating cycle of actomyosin interactions?

Citing Articles

Coupling between phosphate release and force generation in muscle actomyosin.

Takagi Y, Shuman H, Goldman Y Philos Trans R Soc Lond B Biol Sci. 2005; 359(1452):1913-20.

PMID: 15647167 PMC: 1693468. DOI: 10.1098/rstb.2004.1561.

Nucleotide dependent intrinsic fluorescence changes of W29 and W36 in smooth muscle myosin.

van Duffelen M, Chrin L, Berger C Biophys J. 2004; 87(3):1767-75.

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Crystallographic findings on the internally uncoupled and near-rigor states of myosin: further insights into the mechanics of the motor.

Himmel D, Gourinath S, Reshetnikova L, Shen Y, Szent-Gyorgyi A, Cohen C Proc Natl Acad Sci U S A. 2002; 99(20):12645-50.

PMID: 12297624 PMC: 130514. DOI: 10.1073/pnas.202476799.