Acute Lower Respiratory Infections in Hospitalized Children over a 6 Year Period in Tokyo

Overview

Journal Pediatr Int

Specialty Pediatrics

Date 1999 Oct 26

PMID 10530065

Citations 3

Authors

S Sonoda

Y Gotoh

F Bann

T Nakayama

Affiliations

Soon will be listed here.

Abstract

Background: Acute lower respiratory infections are major causes of hospitalization in children and are mainly caused by respiratory viruses. In the present study, we investigated the etiologic agents responsible for acute lower respiratory infections from the period November 1986 to October 1992 in order to determine the seasonal pattern and different characteristics of age distribution of respiratory infectious agents, mainly virus infections.

Methods: A total of 1521 patients with lower respiratory infections was hospitalized in Saiseikai Central Hospital, Tokyo, Japan. Nasopharyngeal secretions were obtained for virus isolation and paired sera in the acute and convalescent phases were obtained for serological examination.

Results: Etiological agents were identified in 668 of 1521 patients (43.9%) by serological antibody responses, virus isolation and/or detection of virus antigen: 240 (15.8%) with respiratory syncytial (RS) virus; 62 (4.1%) with influenza virus type A; 26 (1.7%) with influenza virus type B; 86 (5.7%) with adenovirus; 81 (5.3%) with parainfluenza virus; 32 (2.1%) with measles virus; 20 (1.3%) with enteroviruses or Herpes virus other than respiratory viruses; 75 (4.9%) with Mycoplasma pneumoniae; 10 (0.7%) with pertussis; and 36 (2.4%) with mixed infections. In the remaining 853 patients (56.1%), etiologic agents were not identified. Respiratory syncytial (RS) virus was a main causative agent of respiratory infections in patients younger than 3 years of age. Influenza virus and M. pneumoniae were two main causative agents in patients with acute respiratory illness over 5 years of age. Parainfluenza virus type 3 was frequently observed in infants from 9 to 12 months of age. A distinct seasonal pattern of viral infections was consistently observed in each year during the study period; RS and influenza viruses were prevalent in winter, parainfluenza virus was prevalent in spring and M. pneumoniae was prevalent in summer and autumn. However, adenovirus infections were observed in all seasons. Serological responses were poor in patients younger than 1 year of age and they were mainly diagnosed by virus isolation or detection of virus antigen.

Conclusions: Virological epidemiology provides useful information in daily clinical practice for the prediction of etiological agents based on patient age and the seasonal distribution of agents. We should examine virus isolation and the detection of virus antigen, along with serological examinations in patients with respiratory infections, especially in infants younger than 1 year of age because of poor serological responses.

Citing Articles

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References

Gilchrist S, Torok T, Gary Jr H, Alexander J, Anderson L . National surveillance for respiratory syncytial virus, United States, 1985-1990. J Infect Dis. 1994; 170(4):986-90. DOI: 10.1093/infdis/170.4.986. View

Ghafoor A, Nomani N, Ishaq Z, Zaidi S, Anwar F, Burney M . Diagnoses of acute lower respiratory tract infections in children in Rawalpindi and Islamabad, Pakistan. Rev Infect Dis. 1990; 12 Suppl 8:S907-14. DOI: 10.1093/clinids/12.supplement_8.s907. View

Huq F, Rahman M, Nahar N, Alam A, Haque M, Sack D . Acute lower respiratory tract infection due to virus among hospitalized children in Dhaka, Bangladesh. Rev Infect Dis. 1990; 12 Suppl 8:S982-7. DOI: 10.1093/clinids/12.supplement_8.s982. View

Weissenbacher M, Carballal G, Avila M, Salomon H, Harisiadi J, Catalano M . Etiologic and clinical evaluation of acute lower respiratory tract infections in young Argentinian children: an overview. Rev Infect Dis. 1990; 12 Suppl 8:S889-98. DOI: 10.1093/clinids/12.supplement_8.s889. View

Hortal M, Mogdasy C, Russi J, DeLeon C, Suarez A . Microbial agents associated with pneumonia in children from Uruguay. Rev Infect Dis. 1990; 12 Suppl 8:S915-22. DOI: 10.1093/clinids/12.supplement_8.s915. View

Ruutu P, Halonen P, Meurman O, Torres C, Paladin F, Yamaoka K . Viral lower respiratory tract infections in Filipino children. J Infect Dis. 1990; 161(2):175-9. DOI: 10.1093/infdis/161.2.175. View

Nakayama T, Urano T, OSANO M, Maehara N, Makino S . Alpha interferon in the sera of patients infected with Mycoplasma pneumoniae. J Infect Dis. 1986; 154(5):904-6. DOI: 10.1093/infdis/154.5.904. View

Tupasi T, Lucero M, Magdangal D, Mangubat N, Sunico M, Torres C . Etiology of acute lower respiratory tract infection in children from Alabang, Metro Manila. Rev Infect Dis. 1990; 12 Suppl 8:S929-39. DOI: 10.1093/clinids/12.supplement_8.s929. View

Tupasi T, Velmonte M, Sanvictores M, Abraham L, De Leon L, Tan S . Determinants of morbidity and mortality due to acute respiratory infections: implications for intervention. J Infect Dis. 1988; 157(4):615-23. DOI: 10.1093/infdis/157.4.615. View

10.

Puthavathana P, Wasi C, Kositanont U, Suwanjutha S, Chantarojanasiri T, Kantakamalakul W . A hospital-based study of acute viral infections of the respiratory tract in Thai children, with emphasis on laboratory diagnosis. Rev Infect Dis. 1990; 12 Suppl 8:S988-94. DOI: 10.1093/clinids/12.supplement_8.s988. View

11.

de Arruda E, Hayden F, McAuliffe J, DE SOUSA M, Mota S, McAuliffe M . Acute respiratory viral infections in ambulatory children of urban northeast Brazil. J Infect Dis. 1991; 164(2):252-8. DOI: 10.1093/infdis/164.2.252. View

12.

Jakab G . Mechanisms of virus-induced bacterial superinfections of the lung. Clin Chest Med. 1981; 2(1):59-66. View

13.

Berman S, Duenas A, Bedoya A, Constain V, Leon S, Borrero I . Acute lower respiratory tract illnesses in Cali, Colombia: a two-year ambulatory study. Pediatrics. 1983; 71(2):210-8. View

14.

WINTER G, Inglis J . Respiratory viruses in children admitted to hospital in Edinburgh 1972-1985. J Infect. 1987; 15(1):103-7. DOI: 10.1016/s0163-4453(87)91651-3. View

15.

Suwanjutha S, Chantarojanasiri T, Sirinavin S, Ruangkanchanasetr S, Hotrakitya S, Wasi C . A study of nonbacterial agents of acute lower respiratory tract infection in Thai children. Rev Infect Dis. 1990; 12 Suppl 8:S923-8. DOI: 10.1093/clinids/12.supplement_8.s923. View

16.

Denny F, Collier A, Henderson F . Acute respiratory infections in day care. Rev Infect Dis. 1986; 8(4):527-32. DOI: 10.1093/clinids/8.4.524. View

17.

Denny F, CLYDE Jr W . Acute lower respiratory tract infections in nonhospitalized children. J Pediatr. 1986; 108(5 Pt 1):635-46. DOI: 10.1016/s0022-3476(86)81034-4. View

18.

Anderson L, Parker R, Strikas R . Association between respiratory syncytial virus outbreaks and lower respiratory tract deaths of infants and young children. J Infect Dis. 1990; 161(4):640-6. DOI: 10.1093/infdis/161.4.640. View

19.

Kobune F, Sakata H, Sugiura A . Marmoset lymphoblastoid cells as a sensitive host for isolation of measles virus. J Virol. 1990; 64(2):700-5. PMC: 249163. DOI: 10.1128/JVI.64.2.700-705.1990. View

20.

Waner J . Mixed viral infections: detection and management. Clin Microbiol Rev. 1994; 7(2):143-51. PMC: 358314. DOI: 10.1128/CMR.7.2.143. View