Ramosetron Vs Granisetron for the Prevention of Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Overview

Journal Can J Anaesth

Specialty Anesthesiology

Date 1999 Oct 16

PMID 10522590

Citations 14

Authors

Y Fujii

Y Saitoh

H Tanaka

H Toyooka

Affiliations

Soon will be listed here.

Abstract

Purpose: To compare the efficacy of ramosetron with granisetron for the prevention of postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy.

Methods: In a randomized, double-blind study, 80 female inpatients received 3 mg granisetron or 0.3 mg ramosetron i.v. (n=40 of each) at the completion of surgery The standardized anesthetic included isoflurane and nitrous oxide in oxygen.

Results: Complete response, defined as no PONV, during the first 24 hr (0-24 hr) after anesthesia was 85% with granisetron and 93% with ramosetron, respectively (P=0.241); the corresponding incidence during the next 24 hr (24-48 hr) after anesthesia was 63% and 90% (P=0.004). No clinically important adverse events due to the study drug were observed in any of the groups.

Conclusion: Ramosetron was more effective than granisetron for prevention of PONV during 0-48 hr after anesthesia for laparoscopic cholecystectomy.

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Tomita T, Fukui H, Morishita D, Mori S, Oshima T, Shinzaki S J Clin Med. 2022; 11(23).

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Comparison of equipotent doses of Ramosetron, Ondansetron, and sub-hypnotic dose of Propofol for prevention of postoperative nausea and vomiting in laparoscopic cholecystectomy.

Acharya S, Patil K J Anaesthesiol Clin Pharmacol. 2022; 37(4):517-522.

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Ramosetron for the treatment of irritable bowel syndrome with diarrhea: a systematic review and meta-analysis of randomized controlled trials.

Qi Q, Zhang Y, Chen F, Zuo X, Li Y BMC Gastroenterol. 2018; 18(1):5.

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A Comparative Evaluation of Ramosetron with Ondansetron for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Urological Procedures.

Mujoo S, Ali Z, Jehangir M, Iqbal A, Qayoom N, Lone A Anesth Essays Res. 2017; 11(1):78-83.

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Intravenous palonosetron compared with a combination of ramosetron and dexamethasone in preventing post operative nausea and vomiting in patients undergoing gynaecological surgeries under spinal anaesthesia, a randomised study.

Narayanappa A, Gurulingaswamy S, Prabhakaraiah U, Gurushanth S, Sapare V, Goud N Indian J Anaesth. 2017; 61(2):144-149.

PMID: 28250483 PMC: 5330071. DOI: 10.4103/0019-5049.199851.