Oxygen-independent Microbicidal Mechanisms of Phagocytes

Overview

Journal Proc Assoc Am Physicians

Specialty General Medicine

Date 1999 Oct 16

PMID 10519158

Citations 7

Authors

T Ganz

Affiliations

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Abstract

The principal biological function of phagocytic cells is the destruction of invading microorganisms. Following phagocytosis, microbes are exposed to multiple antimicrobial substances ranging in complexity from simple oxygen radicals to large proteins. These substances disrupt various microbial structures and eventually kill and digest most of the invaders. This review is focused on oxygen-independent microbicidal mechanisms in granulocytes and macrophages.

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