Conservation and Divergence of Axon Guidance Mechanisms

Overview

Journal Curr Opin Neurobiol

Specialties Biology
Neurology

Date 1999 Oct 6

PMID 10508749

Citations 55

Authors

A Chisholm

M Tessier-Lavigne

Affiliations

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Abstract

Analysis of axon guidance mechanisms in vertebrates, Caenorhabditis elegans, and Drosophila melanogaster has led to the identification of several signaling pathways, many of which are strikingly conserved in function. Recent studies indicate that several axon guidance mechanisms are highly conserved in all animals, whereas others, though still conserved in a general sense, show strong evolutionary divergence at a detailed mechanistic level.

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