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From Factors to Mechanisms: Translation and Translational Control in Eukaryotes

Overview
Publisher Elsevier
Specialties Biology
Genetics
Date 1999 Oct 6
PMID 10508691
Citations 51
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Abstract

Biochemical and genetic studies are revealing a network of interactions between eukaryotic translation initiation factors, further refining or redefining perceptions of their function. The notion of translated mRNA as a 'closed-loop' has gained support from the identification of physical and functional interactions between the two mRNA ends and their associated factors. Translational control mechanisms are beginning to unravel in sufficient detail to pinpoint the affected step in the initiation pathway.

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