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» Articles » PMID: 10496942

Role of Gamma Interferon in Controlling Murine Chlamydial Genital Tract Infection

Overview
Journal Infect Immun
Publisher American Society for Microbiology
Specialty Allergy & Immunology
Date 1999 Sep 25
PMID 10496942
Citations 38
Authors
J I Ito
J M Lyons
Affiliations
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Abstract

Earlier investigations have not shown an important role for gamma interferon (IFN-gamma) in the early clearance of chlamydial infection from the murine female genital tract. In a model using a human genital isolate of Chlamydia trachomatis in IFN-gamma and IFN-gamma receptor knockout mice, we were able to demonstrate a major role for IFN-gamma in mediating control of infection throughout the course of infection.

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References
1.
Cotter T, Ramsey K, Miranpuri G, Poulsen C, Byrne G . Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice. Infect Immun. 1997; 65(6):2145-52. PMC: 175296. DOI: 10.1128/iai.65.6.2145-2152.1997. View
2.
Ito Jr J, Harrison H, ALEXANDER E, Billings L . Establishment of genital tract infection in the CF-1 mouse by intravaginal inoculation of a human oculogenital isolate of Chlamydia trachomatis. J Infect Dis. 1984; 150(4):577-82. DOI: 10.1093/infdis/150.4.577. View
3.
Rank R, Ramsey K, Pack E, Williams D . Effect of gamma interferon on resolution of murine chlamydial genital infection. Infect Immun. 1992; 60(10):4427-9. PMC: 257484. DOI: 10.1128/iai.60.10.4427-4429.1992. View
4.
Williams D, Schachter J, Drutz D, Sumaya C . Pneumonia due to Chlamydia trachomatis in the immunocompromised (nude) mouse. J Infect Dis. 1981; 143(2):238-41. DOI: 10.1093/infdis/143.2.238. View
5.
NIGG C . AN UNIDENTIFIED VIRUS WHICH PRODUCES PNEUMONIA AND SYSTEMIC INFECTION IN MICE. Science. 1942; 95(2454):49-50. DOI: 10.1126/science.95.2454.49-a. View