Smad2 and Smad4 Gene Mutations in Hepatocellular Carcinoma

Overview

Journal Oncogene

Specialties Molecular Biology
Oncology

Date 1999 Sep 22

PMID 10490821

Citations 52

Authors

M C Yakicier

M B Irmak

A Romano

M Kew

M Ozturk

Affiliations

Soon will be listed here.

Abstract

TGF-beta is a negative regulator of liver growth. Smad family of genes, as mediators of TGF-beta pathway, are candidate tumor suppressor genes in hepatocellular carcinoma (HCC). We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes. Three tumours displayed somatic mutations; two in Smad4 (Asp332Gly and Cys401Arg) and one in Smad2 (Gln407Arg) genes. All three mutations were A:T --> G:C transitions suspected to result from oxidative stress as observed in mitochondrial DNA. These observation demonstrate that TGF-beta pathway is altered in hepatocellular carcinoma.

Citing Articles

Exploring the Role of the TGF-β Signaling Pathway in Colorectal Precancerous Polyps Biochemical Genetics.

Sadri S, Aghajani A, Soleimani H, Ghorbani Kalkhajeh S, Nazari H, Brouki Milan P Biochem Genet. 2024; .

PMID: 39636332 DOI: 10.1007/s10528-024-10988-y.

Development of the Novel Bifunctional Fusion Protein BR102 That Simultaneously Targets PD-L1 and TGF-β for Anticancer Immunotherapy.

Wu Z, Li N, Gao Z, Chen G, Nie L, Zhou Y Cancers (Basel). 2022; 14(19).

PMID: 36230887 PMC: 9562016. DOI: 10.3390/cancers14194964.

The Role of Cytokines in the Different Stages of Hepatocellular Carcinoma.

Montanari N, Anugwom C, Boonstra A, Debes J Cancers (Basel). 2021; 13(19).

PMID: 34638361 PMC: 8508513. DOI: 10.3390/cancers13194876.

Systematic Analysis of Cytostatic TGF-Beta Response in Mesenchymal-Like Hepatocellular Carcinoma Cell Lines.

Gungor M, Uysal M, Ozturk M, Senturk S J Gastrointest Cancer. 2021; 52(4):1320-1335.

PMID: 34463913 DOI: 10.1007/s12029-021-00704-z.

miR-224 Regulates the Aggressiveness of Hepatoma Cells Through the IL-6/STAT3/SMAD4 Pathway.

An F, Wu X, Zhang Y, Chen D, Lin Y, Wu F Turk J Gastroenterol. 2021; 32(6):532-542.

PMID: 34405820 PMC: 8975471. DOI: 10.5152/tjg.2021.191056.