Long-term Course and Outcome in AIDS Patients with Cerebral Toxoplasmosis

Overview

Journal Acta Neurol Scand

Specialty Neurology

Date 1999 Sep 9

PMID 10478582

Citations 14

Authors

G Arendt

H J von Giesen

H Hefter

E Neuen-Jacob

H ROICK

H Jablonowski

Affiliations

Soon will be listed here.

Abstract

Objectives: We compared clinical long-term course and outcome in all AIDS patients admitted to our outpatient department from January, 1989 to June, 1998 with toxoplasma encephalitis (TE) as first AIDS-defining infection (n= 106) and in 106 patients with Pneumocystis carinii pneumonia (PCP) as first AIDS-defining disease.

Material And Methods: The 2 groups were matched with respect to age, sex, risk group, degree of immunodeficiency as measured by CD4 cell counts and duration of HIV-1-positivity. TE was diagnosed radiologically and by response to treatment.

Results: Forty-three TE patients surviving the first TE symptoms > 14 months developed dementive symptoms, leucoencephalopathy in imaging procedures and died from dementia. In contrast only 5 patients surviving PCP for an equally long period showed dementive symptoms.

Conclusion: Cerebral infections like toxoplasma encephalitis (TE) may negatively influence HIV-1-activity so far latent in the brain.

Citing Articles

Persistence of Human Immunodeficiency Virus-Associated Cerebral Toxoplasmosis Lesions in Successfully Treated Patients Receiving Combination Antiretroviral Therapy.

Coleman B, Smith B, Kapoor R, Proschan M, Sereti I, Hammoud D Open Forum Infect Dis. 2023; 10(5):ofad208.

PMID: 37213420 PMC: 10199119. DOI: 10.1093/ofid/ofad208.

Impact of Plant-Based Foods and Nutraceuticals on Cysts: Nutritional Therapy as a Viable Approach for Managing Chronic Brain Toxoplasmosis.

Tan S, Tong W, Vyas A Front Nutr. 2022; 9:827286.

PMID: 35284438 PMC: 8914227. DOI: 10.3389/fnut.2022.827286.

Injection with protein affects neuron health and survival.

Mendez O, Flores Machado E, Lu J, Koshy A Elife. 2021; 10.

PMID: 34106047 PMC: 8270641. DOI: 10.7554/eLife.67681.

Epidemiology, Pathophysiology, Diagnosis, and Management of Cerebral Toxoplasmosis.

Elsheikha H, Marra C, Zhu X Clin Microbiol Rev. 2020; 34(1).

PMID: 33239310 PMC: 7690944. DOI: 10.1128/CMR.00115-19.

Infections in the immunocompromised child.

Padayachy L, Fieggen A Childs Nerv Syst. 2018; 34(10):1989-1996.

PMID: 29995268 DOI: 10.1007/s00381-018-3893-8.