Directional Guidance of Neuronal Migration in the Olfactory System by the Protein Slit

Overview

Journal Nature

Specialty Science

Date 1999 Aug 4

PMID 10432110

Citations 185

Authors

W Wu

K Wong

J Chen

Z Jiang

S Dupuis

J Y Wu

Y Rao

Affiliations

Soon will be listed here.

Abstract

Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a direct demonstration of a molecular cue whose concentration gradient guides the direction of migrating neurons. They also support a common guidance mechanism for axon projection and neuronal migration and suggest that Slit may provide a molecular tool with potential therapeutic applications in controlling and directing cell migration.

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