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The Cbl Protooncoprotein: a Negative Regulator of Immune Receptor Signal Transduction

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Journal Immunol Today
Date 1999 Aug 4
PMID 10431158
Citations 28
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Abstract

The Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-mediated signal transduction in a variety of cell types. Here, we discuss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.

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