Structural Maintenance of Chromosomes (SMC) Proteins: Conserved Molecular Properties for Multiple Biological Functions

Overview

Journal Eur J Biochem

Specialty Biochemistry

Date 1999 Aug 3

PMID 10429180

Citations 72

Authors

A V Strunnikov

R Jessberger

Affiliations

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Abstract

The evolutionarily-conserved eukaryotic SMC (structural maintenance of chromosomes) proteins are ubiquitous chromosomal components in prokaryotes and eukaryotes. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. The two most prominent and best-characterized complexes are cohesin and condensin, necessary for sister chromatid cohesion and chromosome condensation. Here we discuss these functions together with additional roles in gene dosage compensation and DNA recombination.

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