Hybrid Capture II-based Human Papillomavirus Detection, a Sensitive Test to Detect in Routine High-grade Cervical Lesions: a Preliminary Study on 1518 Women

Overview

Journal Br J Cancer

Specialty Oncology

Date 1999 Jul 29

PMID 10424730

Citations 29

Authors

C Clavel

M Masure

J P Bory

I Putaud

C Mangeonjean

M Lorenzato

R Gabriel

C Quereux

P Birembaut

Affiliations

Soon will be listed here.

Abstract

Hybrid Capture II (HC-II) is a commercial human papillomavirus (HPV) detection test designed to detect 18 HPV types divided into high-risk and low-risk groups. We have tested 1647 scrapes from 1518 unselected women attending routine cytological screening by this assay for the detection of histologically proven high-grade lesions. The reliability of this test was also evaluated on 117 fresh cone biopsy samples. HPV DNA has been detected in 400 scrapes (24.3%), 296 containing a high-risk HPV (18.0%). All the smears evocative of high-grade lesions were positive for high-risk HPV, and high-risk HPV were detected in all the 34 cases presenting a histologically proven high-grade lesion and in 68 (97.1%) of the 70 cone biopsy samples showing a high-grade lesion or an invasive carcinoma. Thus, the sensitivity was superior to the sensitivity of cytology (85.3%). Nevertheless, the quantitative approach provided by the HC-II assay for the assessment of the viral load could not clearly distinguish among cases with or without high-grade lesions. Thus this assay is recommended for the screening of high-grade lesions on a large scale, in association with classic cytology.

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