Characterization of Fractalkine in Rat Brain Cells: Migratory and Activation Signals for CX3CR-1-expressing Microglia

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 1999 Jul 22

PMID 10415068

Citations 123

Authors

S Chen

L Feng

R Maki

K B Bacon

Affiliations

Soon will be listed here.

Abstract

Molecular analyses of the chemokine fractalkine and its receptor CX3C-R1 in the rat brain have revealed a striking polarization: fractalkine is expressed constitutively in neurons and is up-regulated by TNF-alpha and IL-1beta in astrocytes. Expression of its specific receptor, CX3C-R1, is restricted to astrocytes and microglia. We have analyzed the functional correlates of this expression and demonstrate that fractalkine induces microglial cell migration and activation. However, the activity of this chemokine on astrocytes may also be highly relevant in inducing astrocyte-microglia cell interactions through cytokine/mediator release leading to microglial activation.

Citing Articles

CX3CL1 Regulation of Gliosis in Neuroinflammatory and Neuroprotective Processes.

Gutierrez I, Martin-Hernandez D, MacDowell K, Garcia-Bueno B, Caso J, Leza J Int J Mol Sci. 2025; 26(3).

PMID: 39940727 PMC: 11817243. DOI: 10.3390/ijms26030959.

Time-dependent phenotypical changes of microglia drive alterations in hippocampal synaptic transmission in acute slices.

Ferrucci L, Basilico B, Reverte I, Pagani F, Scaringi G, Cordella F Front Cell Neurosci. 2024; 18:1456974.

PMID: 39619853 PMC: 11604457. DOI: 10.3389/fncel.2024.1456974.

Local delivery of soluble fractalkine (CX3CL1) peptide restores ribbon synapses after noise-induced cochlear synaptopathy.

Manickam V, Maity S, Murali S, Gawande D, Stothert A, Batalkina L Front Cell Neurosci. 2024; 18:1486740.

PMID: 39539341 PMC: 11557324. DOI: 10.3389/fncel.2024.1486740.

CX3CR1CD8 T cells: Key players in antitumor immunity.

Ma J, Wu Y, Wu S, Fang Z, Chen L, Jiang J Cancer Sci. 2024; 115(12):3838-3845.

PMID: 39377122 PMC: 11611776. DOI: 10.1111/cas.16359.

Fractalkine/CX3CR1 axis is critical for neuroprotection induced by hypoxic postconditioning against cerebral ischemic injury.

Zhan L, Qiu M, Zheng J, Lai M, Lin K, Dai J Cell Commun Signal. 2024; 22(1):457.

PMID: 39327578 PMC: 11426015. DOI: 10.1186/s12964-024-01830-4.