Mechanism of Antiviral Activity of Triterpenoid Saponins

Overview

Journal Phytother Res

Publisher Wiley

Date 1999 Jul 15

PMID 10404540

Citations 30

Authors

C M Simoes

M Amoros

L GIRRE

Affiliations

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Abstract

Triterpenoid saponins are naturally occurring sugar conjugates of triterpenes possessing various biological activities, including antiviral action. Two substances isolated from natural sources were tested against herpes simplex virus type 1 replication. They did not show evidence of cytotoxicity under antiviral test conditions. The triterpenoid saponin, isolated from a Brazilian plant (s21), represents the oleanane group and inhibited herpes simplex virus type 1 DNA synthesis. The triterpenoid saponin, isolated from a Chinese plant (s17), represents the ursane group and seemed to inhibit viral capsid protein synthesis of herpes simplex virus type 1.

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