Helicobacter Pylori and Apoptosis

Overview

Journal Yale J Biol Med

Specialty Biology

Date 1999 Jun 23

PMID 10378350

Citations 7

Authors

S F Moss

Affiliations

Soon will be listed here.

Abstract

In an attempt to understand the diverse effects of infection with Helicobacter pylori on epithelial mucosal mass and consequent clinical outcome, the relationship between H. pylori infection and gastric epithelial cellular turnover has been investigated. Our results indicate that H. pylori increases epithelial cell proliferation and apoptosis in vivo, but that infection with bacteria of the cagA genotype leads to relatively more proliferation than apoptosis. This review explores the causes of the induction of apoptosis in gastric epithelial cells by H. pylori and the consequences of alterations in apoptosis to the maintenance of gastric mucosal homeostasis.

Citing Articles

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