Neurosecretory Control of Aging in Caenorhabditis Elegans

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1999 Jun 23

PMID 10377425

Citations 52

Authors

M Ailion

T Inoue

C I Weaver

R W Holdcraft

J H Thomas

Affiliations

Soon will be listed here.

Abstract

In the nematode Caenorhabditis elegans, an insulin receptor signaling pathway regulates adult life span and developmental arrest at the dauer larval stage. Here we show that the unc-64 and unc-31 genes also function in this pathway. These two genes are involved in mediating Ca2+-regulated secretion. Mutations in unc-64 and unc-31 increase adult life span and cause constitutive dauer formation. Both phenotypes are suppressed by mutations in daf-16, which also suppresses other mutations in this pathway. We present evidence that the site of action of unc-64 is neuronal, suggesting that a neurosecretory signal regulates life span and dauer formation.

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References

Brenner S . The genetics of Caenorhabditis elegans. Genetics. 1974; 77(1):71-94. PMC: 1213120. DOI: 10.1093/genetics/77.1.71. View

Lakowski B, Hekimi S . The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1998; 95(22):13091-6. PMC: 23719. DOI: 10.1073/pnas.95.22.13091. View

Cassada R, Russell R . The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans. Dev Biol. 1975; 46(2):326-42. DOI: 10.1016/0012-1606(75)90109-8. View

Golden J, Riddle D . A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc Natl Acad Sci U S A. 1984; 81(3):819-23. PMC: 344929. DOI: 10.1073/pnas.81.3.819. View

Golden J, Riddle D . The Caenorhabditis elegans dauer larva: developmental effects of pheromone, food, and temperature. Dev Biol. 1984; 102(2):368-78. DOI: 10.1016/0012-1606(84)90201-x. View

Vowels J, Thomas J . Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics. 1992; 130(1):105-23. PMC: 1204785. DOI: 10.1093/genetics/130.1.105. View

Walent J, PORTER B, Martin T . A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells. Cell. 1992; 70(5):765-75. DOI: 10.1016/0092-8674(92)90310-9. View

Nonet M, Grundahl K, Meyer B, Rand J . Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin. Cell. 1993; 73(7):1291-305. DOI: 10.1016/0092-8674(93)90357-v. View

Avery L, Bargmann C, Horvitz H . The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions. Genetics. 1993; 134(2):455-64. PMC: 1205489. DOI: 10.1093/genetics/134.2.455. View

10.

Thomas J, Birnby D, Vowels J . Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans. Genetics. 1993; 134(4):1105-17. PMC: 1205579. DOI: 10.1093/genetics/134.4.1105. View

11.

Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R . A C. elegans mutant that lives twice as long as wild type. Nature. 1993; 366(6454):461-4. DOI: 10.1038/366461a0. View

12.

Huang L, Tzou P, Sternberg P . The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development. Mol Biol Cell. 1994; 5(4):395-411. PMC: 301050. DOI: 10.1091/mbc.5.4.395. View

13.

Gottlieb S, Ruvkun G . daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans. Genetics. 1994; 137(1):107-20. PMC: 1205929. DOI: 10.1093/genetics/137.1.107. View

14.

Larsen P, Albert P, Riddle D . Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics. 1995; 139(4):1567-83. PMC: 1206485. DOI: 10.1093/genetics/139.4.1567. View

15.

Dorman J, Albinder B, Shroyer T, Kenyon C . The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics. 1995; 141(4):1399-406. PMC: 1206875. DOI: 10.1093/genetics/141.4.1399. View

16.

Morris J, Tissenbaum H, Ruvkun G . A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature. 1996; 382(6591):536-9. DOI: 10.1038/382536a0. View

17.

Miller K, Alfonso A, Nguyen M, Crowell J, Johnson C, Rand J . A genetic selection for Caenorhabditis elegans synaptic transmission mutants. Proc Natl Acad Sci U S A. 1996; 93(22):12593-8. PMC: 38037. DOI: 10.1073/pnas.93.22.12593. View

18.

Iwasaki K, Staunton J, Saifee O, Nonet M, Thomas J . aex-3 encodes a novel regulator of presynaptic activity in C. elegans. Neuron. 1997; 18(4):613-22. DOI: 10.1016/s0896-6273(00)80302-5. View

19.

Kimura K, Tissenbaum H, Liu Y, Ruvkun G . daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997; 277(5328):942-6. DOI: 10.1126/science.277.5328.942. View

20.

Ann K, Kowalchyk J, Loyet K, Martin T . Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis. J Biol Chem. 1997; 272(32):19637-40. DOI: 10.1074/jbc.272.32.19637. View