Mammalian Krüppel-like Transcription Factors: More Than Just a Pretty Finger

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 1999 Jun 15

PMID 10366853

Citations 109

Authors

J Turner

M Crossley

Affiliations

Soon will be listed here.

Abstract

The transcription factor SP1 contains three Krüppel-like zinc fingers. Recently, several related proteins, including erythroid, lung and gut-enriched Krüppel-like factors, have been identified. Together with SP1, these proteins form a sizeable family of transcription factors that share homology in their zinc-finger domains but differ elsewhere. Analysis of these differences is illuminating specific mechanisms by which transcription is regulated.

Citing Articles

Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming.

Chen H, Li L, Du Y Front Pharmacol. 2023; 14:1115226.

PMID: 36937859 PMC: 10017497. DOI: 10.3389/fphar.2023.1115226.

KLF regulation of insulin pathway genes.

Wang H, Brey C, Wang Y, Gaugler R, Hashmi S 3 Biotech. 2023; 13(3):87.

PMID: 36816753 PMC: 9935763. DOI: 10.1007/s13205-023-03502-5.

Krüppel-like Factor 6 Suppresses the Progression of Pancreatic Cancer by Upregulating Activating Transcription Factor 3.

Xiong Q, Zhang Z, Yang Y, Xu Y, Zhou Y, Zhang S J Clin Med. 2023; 12(1).

PMID: 36615000 PMC: 9821328. DOI: 10.3390/jcm12010200.

Roles of Krüppel-like factor 6 splice variant 1 in the development, diagnosis, and possible treatment strategies for non-small cell lung cancer.

Hu K, Ma C, Ma R, Zheng Q, Wang Y, Zhang N Am J Cancer Res. 2022; 12(10):4468-4482.

PMID: 36381325 PMC: 9641401.

KLF5 governs sphingolipid metabolism and barrier function of the skin.

Lyu Y, Guan Y, Deliu L, Humphrey E, Frontera J, Yang Y Genes Dev. 2022; .

PMID: 36008138 PMC: 9480852. DOI: 10.1101/gad.349662.122.