The Expression of the Flagellum of Legionella Pneumophila is Modulated by Different Environmental Factors

Overview

Journal FEMS Microbiol Lett

Publisher Oxford University Press

Specialty Microbiology

Date 1999 Jun 11

PMID 10361710

Citations 18

Authors

K Heuner

B C Brand

J Hacker

Affiliations

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Abstract

Legionella pneumophila, the aetiologic agent of legionnaires' disease, contains a single, monopolar flagellum which is composed of one major subunit, the FlaA protein. Expression studies using a reporter gene fusion of the flaA promoter with the luxAB gene revealed that the flaA expression is not only temperature regulated but is also influenced by the growth phase, the viscosity and the osmolarity of the medium, and by amino acids.

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Protein sociology of ProA, Mip and other secreted virulence factors at the surface.

Scheithauer L, Karagoz M, Mayer B, Steinert M Front Cell Infect Microbiol. 2023; 13:1140688.

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The Flagellar Regulon of A Review.

Appelt S, Heuner K Front Cell Infect Microbiol. 2017; 7:454.

PMID: 29104863 PMC: 5655016. DOI: 10.3389/fcimb.2017.00454.

An investigation of virulence factors of Legionella pneumophila environmental isolates.

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Functional Analysis of the Alternative Sigma-28 Factor FliA and Its Anti-Sigma Factor FlgM of the Nonflagellated Legionella Species L. oakridgensis.

Tlapak H, Rydzewski K, Schulz T, Weschka D, Schunder E, Heuner K J Bacteriol. 2017; 199(11).

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Gillmaier N, Schunder E, Kutzner E, Tlapak H, Rydzewski K, Herrmann V J Biol Chem. 2016; 291(12):6471-82.

PMID: 26792862 PMC: 4813547. DOI: 10.1074/jbc.M115.693481.