Cyclosporin-induced Hypertension: Incidence, Pathogenesis and Management

Overview

Journal Drug Saf

Specialties Pharmacology
Toxicology

Date 1999 May 29

PMID 10348094

Citations 27

Authors

S J Taler

S C Textor

V J Canzanello

L Schwartz

Affiliations

Soon will be listed here.

Abstract

Blood pressure increases soon after administration of immunosuppressive regimens using cyclosporin. Characteristic vascular changes lead to systemic and renal vasoconstriction. Changes in blood pressure are commonly associated with disturbed circadian regulation and may promote the rapid development of target organ injury, including intracranial haemorrhage, left ventricular hypertrophy and microangiopathic haemolysis. The mechanisms underlying this disorder are complex and include altered vascular endothelial function. Vasodilators such as prostacyclin and nitric oxide are suppressed, whereas vasoconstrictors, including endothelin, are increased. Changes in the kidney include vasoconstriction, reduced glomerular filtration and sodium retention. Effective therapy depends upon rigorous blood pressure control by administration of vasodilating agents, with attention to potential interactions with cyclosporin.

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