Bone Scintigraphy in Chronic Knee Pain: Comparison with Magnetic Resonance Imaging

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1999 May 27

PMID 10343536

Citations 17

Authors

T Boegard

O Rudling

J Dahlstrom

H Dirksen

I F Petersson

K Jonsson

Affiliations

Soon will be listed here.

Abstract

Objective: To compare increased bone uptake of 99Tcm-MDP and magnetic resonance (MR) detected subchondral lesions, osteophytes, and cartilage defects in the knee in middle aged people with long-standing knee pain.

Methods: Fifty eight people (aged 41-58 years, mean 50) with chronic knee pain, with or without radiographic knee osteoarthritis, were examined with bone scintigraphy. The pattern and the grade of increased bone uptake was assessed. On the same day, a MR examination on a 1.0 T imager was performed. The presence and the grade of subchondral lesions, osteophytes, and cartilage defects were registered.

Results: The kappa values describing the correlation between increased bone uptake and MR detected subchondral lesions varied between 0.79 and 0.49, and between increased bone uptake and MR detected osteophytes or cartilage defects the values were < 0.54. The kappa values describing the correlation between the grade of bone uptake and the grade of the different MR findings was < 0.57.

Conclusions: Good agreement was found between increased bone uptake and MR detected subchondral lesion. The agreement between increased bone uptake and osteophytes or cartilage defects was in general poor as well as the agreement between the grade of bone uptake and the grade of the MR findings.

Citing Articles

Can bone scintigraphy reflect the progression of osteoarthritis after unicompartmental knee arthroplasty?.

Lim S, Kim T, Park D, Lee J, Chung J PLoS One. 2023; 18(11):e0288616.

PMID: 37939074 PMC: 10631669. DOI: 10.1371/journal.pone.0288616.

[F]NaF PET-MRI provides direct in-vivo evidence of the association between bone metabolic activity and adjacent synovitis in knee osteoarthritis: a cross-sectional study.

MacKay J, Watkins L, Gold G, Kogan F Osteoarthritis Cartilage. 2021; 29(8):1155-1162.

PMID: 33975018 PMC: 8319134. DOI: 10.1016/j.joca.2021.04.014.

The role of hybrid bone SPECT/CT imaging in the work-up of the limping patient: a symptom-based and joint-oriented review.

Mohan H, Strobel K, van der Bruggen W, Gnanasegaran G, Kampen W, Kuwert T Eur J Hybrid Imaging. 2018; 2(1):8.

PMID: 29782592 PMC: 5954706. DOI: 10.1186/s41824-018-0026-2.

Good clinical results but moderate osseointegration and defect filling of a cell-free multi-layered nano-composite scaffold for treatment of osteochondral lesions of the knee.

Mathis D, Kaelin R, Rasch H, Arnold M, Hirschmann M Knee Surg Sports Traumatol Arthrosc. 2017; 26(4):1273-1280.

PMID: 28712029 DOI: 10.1007/s00167-017-4638-z.

Increased bone tracer uptake in symptomatic patients with ACL graft insufficiency: a correlation of MRI and SPECT/CT findings.

Mathis D, Hirschmann A, Falkowski A, Kiekara T, Amsler F, Rasch H Knee Surg Sports Traumatol Arthrosc. 2017; 26(2):563-573.

PMID: 28551834 DOI: 10.1007/s00167-017-4588-5.

References

Hutton C, Higgs E, Jackson P, Watt I, Dieppe P . 99mTc HMDP bone scanning in generalised nodal osteoarthritis. I. Comparison of the standard radiograph and four hour bone scan image of the hand. Ann Rheum Dis. 1986; 45(8):617-21. PMC: 1001955. DOI: 10.1136/ard.45.8.617. View

Dye S, Boll D . Radionuclide imaging of the patellofemoral joint in young adults with anterior knee pain. Orthop Clin North Am. 1986; 17(2):249-62. View

Gross W, Lohmann C, Ludemann G, Ludemann J . Lymphocyte response to enterobacterial biostructures in seronegative spondarthritis: specific T-cell mediated immunity or non-specific polyclonal B-cell activation?. Br J Rheumatol. 1988; 27 Suppl 2:23-8. DOI: 10.1093/rheumatology/xxvii.suppl_2.23. View

Egund N, Frost S, BRISMAR J, Gustafson T . Radiography and scintigraphy in the assessment of early gonarthrosis. Acta Radiol. 1988; 29(4):451-5. View

Hayes C, Sawyer R, Conway W . Patellar cartilage lesions: in vitro detection and staging with MR imaging and pathologic correlation. Radiology. 1990; 176(2):479-83. DOI: 10.1148/radiology.176.2.2367664. View

Karvonen R, Negendank W, Fraser S, Mayes M, An T, Fernandez-Madrid F . Articular cartilage defects of the knee: correlation between magnetic resonance imaging and gross pathology. Ann Rheum Dis. 1990; 49(9):672-5. PMC: 1004201. DOI: 10.1136/ard.49.9.672. View

Dieppe P . Osteoarthritis: clinical and research perspective. Br J Rheumatol. 1991; 30 Suppl 1:1-4. View

McAlindon T, Watt I, McCrae F, Goddard P, Dieppe P . Magnetic resonance imaging in osteoarthritis of the knee: correlation with radiographic and scintigraphic findings. Ann Rheum Dis. 1991; 50(1):14-9. PMC: 1004317. DOI: 10.1136/ard.50.1.14. View

Heron C, Calvert P . Three-dimensional gradient-echo MR imaging of the knee: comparison with arthroscopy in 100 patients. Radiology. 1992; 183(3):839-44. DOI: 10.1148/radiology.183.3.1584944. View

10.

McAlindon T, Snow S, Cooper C, Dieppe P . Radiographic patterns of osteoarthritis of the knee joint in the community: the importance of the patellofemoral joint. Ann Rheum Dis. 1992; 51(7):844-9. PMC: 1004766. DOI: 10.1136/ard.51.7.844. View

11.

McCrae F, Shouls J, Dieppe P, Watt I . Scintigraphic assessment of osteoarthritis of the knee joint. Ann Rheum Dis. 1992; 51(8):938-42. PMC: 1004798. DOI: 10.1136/ard.51.8.938. View

12.

Bagge E, Bjelle A, Svanborg A . Radiographic osteoarthritis in the elderly. A cohort comparison and a longitudinal study of the "70-year old people in Göteborg". Clin Rheumatol. 1992; 11(4):486-91. DOI: 10.1007/BF02283103. View

13.

Tervonen O, Dietz M, Carmichael S, Ehman R . MR imaging of knee hyaline cartilage: evaluation of two- and three-dimensional sequences. J Magn Reson Imaging. 1993; 3(4):663-8. DOI: 10.1002/jmri.1880030417. View

14.

Brown T, Quinn S . Evaluation of chondromalacia of the patellofemoral compartment with axial magnetic resonance imaging. Skeletal Radiol. 1993; 22(5):325-8. DOI: 10.1007/BF00198391. View

15.

Mirowitz S, Apicella P, Reinus W, Hammerman A . MR imaging of bone marrow lesions: relative conspicuousness on T1-weighted, fat-suppressed T2-weighted, and STIR images. AJR Am J Roentgenol. 1994; 162(1):215-21. DOI: 10.2214/ajr.162.1.8273669. View

16.

Broderick L, Turner D, Renfrew D, Schnitzer T, Huff J, Harris C . Severity of articular cartilage abnormality in patients with osteoarthritis: evaluation with fast spin-echo MR vs arthroscopy. AJR Am J Roentgenol. 1994; 162(1):99-103. DOI: 10.2214/ajr.162.1.8273700. View

17.

Smith R, Constable R, Reinhold C, McCauley T, Lange R, McCarthy S . Fast spin echo STIR imaging. J Comput Assist Tomogr. 1994; 18(2):209-13. DOI: 10.1097/00004728-199403000-00007. View

18.

Peterfy C, van Dijke C, Janzen D, Gluer C, Namba R, Majumdar S . Quantification of articular cartilage in the knee with pulsed saturation transfer subtraction and fat-suppressed MR imaging: optimization and validation. Radiology. 1994; 192(2):485-91. DOI: 10.1148/radiology.192.2.8029420. View

19.

Hilfiker P, Zanetti M, Debatin J, McKinnon G, Hodler J . Fast spin-echo inversion-recovery imaging versus fast T2-weighted spin-echo imaging in bone marrow abnormalities. Invest Radiol. 1995; 30(2):110-4. DOI: 10.1097/00004424-199502000-00009. View

20.

Recht M, Piraino D, Paletta G, Schils J, Belhobek G . Accuracy of fat-suppressed three-dimensional spoiled gradient-echo FLASH MR imaging in the detection of patellofemoral articular cartilage abnormalities. Radiology. 1996; 198(1):209-12. DOI: 10.1148/radiology.198.1.8539380. View