UDP-GlcNAc 2-epimerase: a Regulator of Cell Surface Sialylation

Overview

Journal Science

Specialty Science

Date 1999 May 21

PMID 10334995

Citations 114

Authors

O T Keppler

S Hinderlich

J Langner

R Schwartz-Albiez

W REUTTER

M Pawlita

Affiliations

Soon will be listed here.

Abstract

Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.

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