FOG-2, a Heart- and Brain-enriched Cofactor for GATA Transcription Factors

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1999 May 18

PMID 10330188

Citations 71

Authors

J R Lu

T A McKinsey

H Xu

D Z Wang

J A Richardson

E N Olson

Affiliations

Soon will be listed here.

Abstract

Members of the GATA family of zinc finger transcription factors have been shown to play important roles in the control of gene expression in a variety of cell types. GATA-1, -2, and -3 are expressed primarily in hematopoietic cell lineages and are required for proliferation and differentiation of multiple hematopoietic cell types, whereas GATA-4, -5, and -6 are expressed in the heart, where they activate cardiac muscle structural genes. Friend of GATA-1 (FOG) is a multitype zinc finger protein that interacts with GATA-1 and serves as a cofactor for GATA-1-mediated transcription. FOG is coexpressed with GATA-1 in developing erythroid and megakaryocyte cell lineages and cooperates with GATA-1 to control erythropoiesis. We describe a novel FOG-related factor, FOG-2, that is expressed predominantly in the developing and adult heart, brain, and testis. FOG-2 interacts with GATA factors, and interaction of GATA-4 and FOG-2 results in either synergistic activation or repression of GATA-dependent cardiac promoters, depending on the specific promoter and the cell type in which they are tested. The properties of FOG-2 suggest its involvement in the control of cardiac and neural gene expression by GATA transcription factors.

Citing Articles

Role of genetics and the environment in the etiology of congenital diaphragmatic hernia.

Liu S, Yu L World J Pediatr Surg. 2024; 7(3):e000884.

PMID: 39183805 PMC: 11340715. DOI: 10.1136/wjps-2024-000884.

Molecular Pathways and Animal Models of Tricuspid Atresia and Univentricular Heart.

Shibbani K, Nemer G Adv Exp Med Biol. 2024; 1441:885-900.

PMID: 38884757 DOI: 10.1007/978-3-031-44087-8_55.

Human Genetics of Tricuspid Atresia and Univentricular Heart.

Sleiman A, Sadder L, Nemer G Adv Exp Med Biol. 2024; 1441:875-884.

PMID: 38884756 DOI: 10.1007/978-3-031-44087-8_54.

Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival.

Neufeldt D, Schmidt A, Mohr E, Lu D, Chatterjee S, Fuchs M Basic Res Cardiol. 2024; 119(4):613-632.

PMID: 38639887 PMC: 11319402. DOI: 10.1007/s00395-024-01048-y.

Variants in Candidate Genes for Phenotype Heterogeneity in Patients with the 22q11.2 Deletion Syndrome.

Nunes N, Nunes B, Zamariolli M, de Queiroz Soares D, Caires Dos Santos L, Dantas A Genet Res (Camb). 2024; 2024:5549592.

PMID: 38586596 PMC: 10998724. DOI: 10.1155/2024/5549592.

References

Kulessa H, Frampton J, Graf T . GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts. Genes Dev. 1995; 9(10):1250-62. DOI: 10.1101/gad.9.10.1250. View

Kuo C, Morrisey E, Anandappa R, Sigrist K, Lu M, Parmacek M . GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997; 11(8):1048-60. DOI: 10.1101/gad.11.8.1048. View

Tsang A, Fujiwara Y, Hom D, Orkin S . Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev. 1998; 12(8):1176-88. PMC: 316724. DOI: 10.1101/gad.12.8.1176. View

Yamamoto M, Ko L, Leonard M, Beug H, Orkin S, Engel J . Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes Dev. 1990; 4(10):1650-62. DOI: 10.1101/gad.4.10.1650. View

Thuerauf D, Hanford D, Glembotski C . Regulation of rat brain natriuretic peptide transcription. A potential role for GATA-related transcription factors in myocardial cell gene expression. J Biol Chem. 1994; 269(27):17772-5. View

Cubadda Y, Heitzler P, Ray R, Bourouis M, Ramain P, Gelbart W . u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila. Genes Dev. 1997; 11(22):3083-95. PMC: 316693. DOI: 10.1101/gad.11.22.3083. View

Lien C, Wu C, Mercer B, Webb R, Richardson J, Olson E . Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer. Development. 1998; 126(1):75-84. DOI: 10.1242/dev.126.1.75. View

Jiang Y, Evans T . The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Dev Biol. 1996; 174(2):258-70. DOI: 10.1006/dbio.1996.0071. View

Tsai F, Keller G, Kuo F, Weiss M, Chen J, Rosenblatt M . An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 1994; 371(6494):221-6. DOI: 10.1038/371221a0. View

10.

Visvader J, Crossley M, Hill J, Orkin S, Adams J . The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line. Mol Cell Biol. 1995; 15(2):634-41. PMC: 231921. DOI: 10.1128/MCB.15.2.634. View

11.

Laverriere A, MacNeill C, Mueller C, Poelmann R, Burch J, Evans T . GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut. J Biol Chem. 1994; 269(37):23177-84. View

12.

Shivdasani R, Fujiwara Y, McDevitt M, Orkin S . A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997; 16(13):3965-73. PMC: 1170020. DOI: 10.1093/emboj/16.13.3965. View

13.

Ting C, Olson M, Barton K, Leiden J . Transcription factor GATA-3 is required for development of the T-cell lineage. Nature. 1996; 384(6608):474-8. DOI: 10.1038/384474a0. View

14.

Tsang A, Visvader J, Turner C, Fujiwara Y, Yu C, Weiss M . FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell. 1997; 90(1):109-19. DOI: 10.1016/s0092-8674(00)80318-9. View

15.

Durocher D, Chen C, Ardati A, Schwartz R, Nemer M . The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium. Mol Cell Biol. 1996; 16(9):4648-55. PMC: 231464. DOI: 10.1128/MCB.16.9.4648. View

16.

Lachman H, SKOULTCHI A . Expression of c-myc changes during differentiation of mouse erythroleukaemia cells. Nature. 1984; 310(5978):592-4. DOI: 10.1038/310592a0. View

17.

Searcy R, Vincent E, Liberatore C, Yutzey K . A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice. Development. 1998; 125(22):4461-70. DOI: 10.1242/dev.125.22.4461. View

18.

Gove C, Walmsley M, Nijjar S, Bertwistle D, Guille M, Partington G . Over-expression of GATA-6 in Xenopus embryos blocks differentiation of heart precursors. EMBO J. 1997; 16(2):355-68. PMC: 1169641. DOI: 10.1093/emboj/16.2.355. View

19.

Pevny L, Simon M, Robertson E, Klein W, Tsai S, DAgati V . Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 1991; 349(6306):257-60. DOI: 10.1038/349257a0. View

20.

Lee Y, SHIOI T, Kasahara H, Jobe S, Wiese R, Markham B . The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol Cell Biol. 1998; 18(6):3120-9. PMC: 108894. DOI: 10.1128/MCB.18.6.3120. View