Sterol Regulatory Element-binding Proteins: Activators of Cholesterol and Fatty Acid Biosynthesis

Overview

Journal Curr Opin Lipidol

Specialty Biochemistry

Date 1999 May 18

PMID 10327282

Citations 72

Authors

J D Horton

I Shimomura

Affiliations

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Abstract

A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes.

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