The WD Repeat: a Common Architecture for Diverse Functions

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 1999 May 14

PMID 10322433

Citations 483

Authors

T F Smith

C Gaitatzes

K Saxena

E J Neer

Affiliations

Soon will be listed here.

Abstract

Our knowledge of the large family of proteins that contain the WD repeat continues to accumulate. The WD-repeat proteins are found in all eukaryotes and are implicated in a wide variety of crucial functions. The solution of the three-dimensional structure of one WD-repeat protein and the assumption that the structure will be common to all members of this family has allowed subfamilies of WD-repeat proteins to be defined on the basis of probable surface similarity. Proteins that have very similar surfaces are likely to have common binding partners and similar functions.

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