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Retinoblastoma Protein Meets Chromatin

Overview
Specialty Biochemistry
Date 1999 May 14
PMID 10322419
Citations 52
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Abstract

The retinoblastoma (RB) protein exerts its tumour-suppressor function by repressing the transcription of cellular genes required for DNA replication and cell division. Recent investigations into the mechanism of RB repression have revealed that RB can regulate transcription by effecting changes in chromatin structure. These findings point towards a link between chromatin regulation and cancer.

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