Analysis of B-cell Epitopes of the Ro/SS-A Autoantigen

Overview

Journal Immunol Today

Specialty Allergy & Immunology

Date 1999 May 14

PMID 10322303

Citations 19

Authors

M Wahren-Herlenius

S Muller

D Isenberg

Affiliations

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Abstract

Autoantibodies to the Ro and La ribonucleoprotein antigens are found in several rheumatoid diseases. The important epitopes have been studied using synthetic peptides and recombinant antigens to understand how they arise and their implication in disease. Here, we analyse the results of epitope mapping studies of Ro60 and Ro52 autoantigens and focus on the major findings to date.

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Anti-Ro60 Seropositivity Determines Anti-Ro52 Epitope Mapping in Patients With Systemic Sclerosis.

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Immune response against the coiled coil domain of Sjögren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction.

Sroka M, Bagavant H, Biswas I, Ballard A, Deshmukh U Clin Exp Rheumatol. 2018; 36 Suppl 112(3):41-46.

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