Clonal Evolution of B Cells in Transformation from Low- to High-grade Lymphoma

Overview

Journal Eur J Immunol

Specialty Allergy & Immunology

Date 1999 May 6

PMID 10229093

Citations 19

Authors

A Matolcsy

E J Schattner

D M Knowles

P Casali

Affiliations

Soon will be listed here.

Abstract

An outcome of low-grade B cell non-Hodgkins's lymphomas is the transformation to high-grade diffuse large B cell lymphomas (DLBL). To investigate the mechanisms of clonal evolution in the transformation to DLBL, we performed longitudinal molecular analyses of immunoglobulin (Ig), V(H)DJ(H) gene sequences expressed in cases of chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and follicular lymphoma (FL) that transformed to DLBL. Among the neoplastic CLL and SLL cells and their respective high-grade transformants, there was no evidence for a clonotypic shift or acquired mutations in the expressed Ig V(H)DJ(H) gene segments, as further confirmed by a specific and sensitive PCR-single strand polymorphism analysis. In contrast, among the FL cells there was a high degree of intraclonal diversification with highly divergent V(H)DJ(H) gene sequences. Despite this intraclonal heterogeneity, the related DLBL expressed a collinear but unique V(H)DJ(H) gene sequence. The intraclonal genealogical tree for the FL case demonstrated that the DLBL emerged in association with unique V(H)DJ(H) gene mutational events. Among the intraclonal FL and related DLBL transformants, the nature and distribution of the Ig V(H)DJ(H) gene mutations were consistent with antigenic selection. Thus, clonal evolution in the transformation from low- to high-grade B cell lymphoma may involve distinct pathways which vary according to the cellular origin and the type of the progenitor B cell tumor.

Citing Articles

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References

Schettino E, Chai S, Kasaian M, Schroeder Jr H, Casali P . VHDJH gene sequences and antigen reactivity of monoclonal antibodies produced by human B-1 cells: evidence for somatic selection. J Immunol. 1997; 158(5):2477-89. PMC: 4631314. View

Bahler D, Levy R . Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc Natl Acad Sci U S A. 1992; 89(15):6770-4. PMC: 49585. DOI: 10.1073/pnas.89.15.6770. View

Cullen M, Lister T, Brearley R, Shand W, Stansfeld A . Histological transformation of non-Hodgkin's lymphoma: a prospective study. Cancer. 1979; 44(2):645-51. DOI: 10.1002/1097-0142(197908)44:2<645::aid-cncr2820440234>3.0.co;2-y. View

Roncella S, Cutrona G, Favre A, Ulivi M, Fais F, Signorini A . Apoptosis of Burkitt's lymphoma cells induced by specific interaction of surface IgM with a self-antigen: implications for lymphomagenesis in acquired immunodeficiency syndrome. Blood. 1996; 88(2):599-608. View

Matsuda F, Shin E, Nagaoka H, Matsumura R, Haino M, Fukita Y . Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus. Nat Genet. 1993; 3(1):88-94. DOI: 10.1038/ng0193-88. View

Matolcsy A, Casali P, Nador R, Liu Y, Knowles D . Molecular characterization of IgA- and/or IgG-switched chronic lymphocytic leukemia B cells. Blood. 1997; 89(5):1732-9. PMC: 4631049. View

Matolcsy A, Inghirami G, Knowles D . Molecular genetic demonstration of the diverse evolution of Richter's syndrome (chronic lymphocytic leukemia and subsequent large cell lymphoma). Blood. 1994; 83(5):1363-72. View

Matsuda F, Ishii K, Bourvagnet P, Kuma K, Hayashida H, Miyata T . The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med. 1998; 188(11):2151-62. PMC: 2212390. DOI: 10.1084/jem.188.11.2151. View

Matolcsy A, Casali P, Warnke R, Knowles D . Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene. Blood. 1996; 88(10):3937-44. View

10.

Yano T, Jaffe E, Longo D, Raffeld M . MYC rearrangements in histologically progressed follicular lymphomas. Blood. 1992; 80(3):758-67. View

11.

Rassenti L, Kipps T . Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia. J Exp Med. 1993; 177(4):1039-46. PMC: 2190987. DOI: 10.1084/jem.177.4.1039. View

12.

Zelenetz A, Chen T, Levy R . Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection. J Exp Med. 1992; 176(4):1137-48. PMC: 2119381. DOI: 10.1084/jem.176.4.1137. View

13.

Jain R, Roncella S, Hashimoto S, Carbone A, Francia di Celle P, Foa R . A potential role for antigen selection in the clonal evolution of Burkitt's lymphoma. J Immunol. 1994; 153(1):45-52. View

14.

Gaidano G, Ballerini P, Gong J, Inghirami G, Neri A, Newcomb E . p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 1991; 88(12):5413-7. PMC: 51883. DOI: 10.1073/pnas.88.12.5413. View

15.

Crescenzi M, Seto M, Herzig G, Weiss P, Griffith R, Korsmeyer S . Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease. Proc Natl Acad Sci U S A. 1988; 85(13):4869-73. PMC: 280538. DOI: 10.1073/pnas.85.13.4869. View

16.

Hubbard S, Chabner B, Devita Jr V, Simon R, BERARD C, Jones R . Histologic progression in non-Hodgkin's lymphoma. Blood. 1982; 59(2):258-64. View

17.

Kipps T . Immunoglobulin genes in chronic lymphocytic leukemia. Blood Cells. 1993; 19(3):615-25; discussion 631-2. View

18.

Harris N, Jaffe E, STEIN H, Banks P, Chan J, Cleary M . A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994; 84(5):1361-92. View

19.

Ersboll J, Schultz H, Pedersen-Bjergaard J, Nissen N . Follicular low-grade non-Hodgkin's lymphoma: long-term outcome with or without tumor progression. Eur J Haematol. 1989; 42(2):155-63. DOI: 10.1111/j.1600-0609.1989.tb01205.x. View

20.

Tomlinson I, Walter G, Marks J, Llewelyn M, Winter G . The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J Mol Biol. 1992; 227(3):776-98. DOI: 10.1016/0022-2836(92)90223-7. View