The Pharmacological Basis and Pathophysiological Significance of the Heart Rate-lowering Property of Diltiazem

Overview

Journal Fundam Clin Pharmacol

Specialty Pharmacology

Date 1999 May 5

PMID 10226758

Citations 12

Authors

S E OConnor

A Grosset

P Janiak

Affiliations

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Abstract

The calcium channel blocker diltiazem lowers heart rate in man and this property probably contributes to its clinical effectiveness in ischaemic heart disease and hypertension. This review examines the pharmacological basis of diltiazem's heart rate-lowering activity and considers its pathophysiological significance. The points discussed include the potent direct inhibitory effect of diltiazem on the sinus node and the frequency-dependence of this action. In addition, the well-balanced tissue selectivity profile of diltiazem and its ability to modulate cardiac reflex responsiveness contribute by counteracting the potential for reflex tachycardia.

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