Comparative Effects of Antilactoferrin Antibodies and Tumor Necrosis Factor on Neutrophil Adherence to Matrix Proteins

Overview

Journal Clin Diagn Lab Immunol

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1999 May 4

PMID 10225837

Citations 2

Authors

B Zweiman

C von Allmen

Affiliations

Soon will be listed here.

Abstract

Neutrophil adherence to matrix proteins likely plays an important role in inflammatory responses. Antineutrophil cytoplasm antibodies may activate neutrophils in certain diseases. Using an in vitro method that allows simultaneous quantitation of neutrophil adherence and superoxide secretion, we compared the effects of antibodies against neutrophil granule proteins and tumor necrosis factor alpha (TNF-alpha), a known neutrophil agonist. Antilactoferrin antibodies but not antielastase or antimyeloperoxidase antibodies stimulated increased adherence to fibronectin and laminin similar in degree to that induced by TNF-alpha. This, but not the simultaneous superoxide secretion, was inhibited in the presence of anti-CD18 antibodies. Humoral immune responses to lactoferrin, likely expressed on the neutrophil surface, can activate neutrophils in proinflammatory responses that may be pathogenic.

Citing Articles

A Novel Murine Anti-Lactoferrin Monoclonal Antibody Activates Human Polymorphonuclear Leukocytes through Membrane-Bound Lactoferrin and TLR4.

Hu X, Xu Y, Yan R, Sun S, Dong H, Wang J Biomed Res Int. 2015; 2015:285237.

PMID: 26649297 PMC: 4662965. DOI: 10.1155/2015/285237.

Antineutrophil cytoplasmic antibodies in Bulgarian patients with rheumatoid arthritis: characterization and clinical associations.

Manolova I, Dantcheva M Rheumatol Int. 2005; 26(2):107-14.

PMID: 16341903 DOI: 10.1007/s00296-004-0517-2.

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