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Bordatella Pertussis Adenylate Cyclase: a Toxin with Multiple Talents

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Date 1999 Apr 28
PMID 10217833
Citations 122
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Abstract

Bordetella pertussis secretes a calmodulin-activated adenylate cyclase toxin (CyaA) that is able to deliver its amino-terminal catalytic domain into the cytosol of eukaryotic cells. The novelty of the structural organization and conformational flexibility of the CyaA catalytic domain has opened up the way for exploiting this protein as a tool for several biological applications, including epitope delivery, protein targeting and characterization of protein-protein interactions.

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