HIV: The Deadly Passenger in Dendritic Cells

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 1999 Apr 21

PMID 10209110

Citations 16

Authors

S L Rowland-Jones

Affiliations

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Abstract

A picture is emerging of how HIV subverts a normal immunological surveillance mechanism to establish primary infection. This involves the infection of dendritic cells at mucosal surfaces: as these cells then mature, they transport the virus to lymphoid tissue, where viral replication begins and infection of CD4(+) T cells occurs.

Citing Articles

Multiploid inheritance of HIV-1 during cell-to-cell infection.

Del Portillo A, Tripodi J, Najfeld V, Wodarz D, Levy D, Chen B J Virol. 2011; 85(14):7169-76.

PMID: 21543479 PMC: 3126592. DOI: 10.1128/JVI.00231-11.

SDF-1/CXCL12 production by mature dendritic cells inhibits the propagation of X4-tropic HIV-1 isolates at the dendritic cell-T-cell infectious synapse.

Gonzalez N, Bermejo M, Calonge E, Jolly C, Arenzana-Seisdedos F, Pablos J J Virol. 2010; 84(9):4341-51.

PMID: 20181695 PMC: 2863755. DOI: 10.1128/JVI.02449-09.

Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4+ T-lymphocytes.

Naarding M, Baan E, Pollakis G, Paxton W Retrovirology. 2007; 4:6.

PMID: 17263871 PMC: 1796897. DOI: 10.1186/1742-4690-4-6.

Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1.

Groot F, Kuijpers T, Berkhout B, de Jong E Retrovirology. 2006; 3:75.

PMID: 17078873 PMC: 1635562. DOI: 10.1186/1742-4690-3-75.

Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4+ T cells.

Naarding M, Dirac A, Ludwig I, Speijer D, Lindquist S, Vestman E Antimicrob Agents Chemother. 2006; 50(10):3367-74.

PMID: 17005819 PMC: 1610064. DOI: 10.1128/AAC.00593-06.