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Fragile X Premutation is a Significant Risk Factor for Premature Ovarian Failure: the International Collaborative POF in Fragile X Study--preliminary Data

Overview
Journal Am J Med Genet
Specialty Genetics
Date 1999 Apr 20
PMID 10208170
Citations 142
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Abstract

The preliminary results of an international collaborative study examining premature menopause in fragile X carriers are presented. A total of 760 women from fragile X families was surveyed about their fragile X carrier status and their menstrual and reproductive histories. Among the subjects, 395 carried a premutation, 128 carried a full mutation, and 237 were noncarriers. Sixty-three (16%) of the premutation carriers had experienced menopause prior to the age of 40 compared with none of the full mutation carriers and one (0.4%) of the controls. Based on these preliminary data, there is a significant association between fragile X premutation carrier status and premature menopause.

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