Immune Cell Signaling Defects in Lupus: Activation, Anergy and Death

Overview

Journal Immunol Today

Specialty Allergy & Immunology

Date 1999 Apr 22

PMID 10203702

Citations 24

Authors

G C Tsokos

S N Liossis

Affiliations

Soon will be listed here.

Abstract

Recent studies have identified novel aberrations in antigen receptor-mediated signaling events in lymphocytes from patients with systemic lupus erythematosus. Here, we propose that in lupus lymphocytes, the receptor-mediated increase in protein tyrosine phosphorylation and cytoplasmic free Ca2+ responses, along with T-cell receptor zeta chain deficiency, might explain the previously described diverse and conflicting immunoregulatory defects in human lupus.

Citing Articles

Calcineurin and Systemic Lupus Erythematosus: The Rationale for Using Calcineurin Inhibitors in the Treatment of Lupus Nephritis.

Rafael-Vidal C, Altabas I, Perez N, Mourino Rodriguez C, Pego-Reigosa J, Garcia S Int J Mol Sci. 2021; 22(3).

PMID: 33514066 PMC: 7865978. DOI: 10.3390/ijms22031263.

Lys63-polyubiquitination by the E3 ligase casitas B-lineage lymphoma-b (Cbl-b) modulates peripheral regulatory T cell tolerance in patients with systemic lupus erythematosus.

Romo-Tena J, Rajme-Lopez S, Aparicio-Vera L, Alcocer-Varela J, Gomez-Martin D Clin Exp Immunol. 2017; 191(1):42-49.

PMID: 28940360 PMC: 5721239. DOI: 10.1111/cei.13054.

XRCC1 Arg399Gln and Arg194Trp polymorphisms and risk of systemic lupus erythematosus in an Iranian population: a pilot study.

Salimi S, Mohammadoo-Khorasani M, Tabatabai E, Sandoughi M, Zakeri Z, Naghavi A Biomed Res Int. 2014; 2014:492956.

PMID: 24971336 PMC: 4058225. DOI: 10.1155/2014/492956.

Deranged bioenergetics and defective redox capacity in T lymphocytes and neutrophils are related to cellular dysfunction and increased oxidative stress in patients with active systemic lupus erythematosus.

Li K, Wu C, Hsieh S, Lu M, Tsai C, Yu C Clin Dev Immunol. 2011; 2012:548516.

PMID: 22007252 PMC: 3191817. DOI: 10.1155/2012/548516.

Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features.

Crowe S, Merrill J, Vista E, Dedeke A, Thompson D, Stewart S Arthritis Rheum. 2011; 63(8):2396-406.

PMID: 21598235 PMC: 3149742. DOI: 10.1002/art.30388.