Catalytic Promiscuity and the Evolution of New Enzymatic Activities

Overview

Journal Chem Biol

Publisher Elsevier

Specialties Biochemistry
Biology
Chemistry

Date 1999 Apr 1

PMID 10099128

Citations 233

Authors

P J OBrien

D Herschlag

Affiliations

Soon will be listed here.

Abstract

Several contemporary enzymes catalyze alternative reactions distinct from their normal biological reactions. In some cases the alternative reaction is similar to a reaction that is efficiently catalyzed by an evolutionary related enzyme. Alternative activities could have played an important role in the diversification of enzymes by providing a duplicated gene a head start towards being captured by adaptive evolution.

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