A Possible Active Segment on the Inactive Human X Chromosome

Overview

Journal Chromosoma

Specialty Molecular Biology

Date 1976 Dec 16

PMID 1009814

Citations 21

Authors

E THERMAN

G E Sarto

C Disteche

C Denniston

Affiliations

Soon will be listed here.

Abstract

An idic(Xp--) in which the two X chromosomes are attached short arm to short arm, and which thus has two b regions (the Q-dark segment next to the centromere on Xp) between the inactivation centers, assumed to be situated on the Q-dark region next to the centromere on Xq, showed 63.8% bipartite Barr bodies as compared with 22.2% formed by idic(Xq--). In addition, the mean distance of the two parts of the Barr bodies in the fibroblasts of a patient with idic(Xp--) is significantly greater than in the cases with one or no b region. Contrary to the other patients with abnormal X chromosomes, the buccal cells of a woman idic(Xp--) showed a number of bipartite Barr bodies. -- To explain these observations we have put forward the hypothesis that the b region on the Xp always remains active and thus, when the rest of the chromosome forms a Barr body, this segment is extended, allowing the two parts of the X chromatin to get farther apart and at the same time increasing the percentage of bipartite bodies.

Citing Articles

Structural aspects of the inactive X chromosome.

Bonora G, Disteche C Philos Trans R Soc Lond B Biol Sci. 2017; 372(1733).

PMID: 28947656 PMC: 5627159. DOI: 10.1098/rstb.2016.0357.

Chromosomal basis of X chromosome inactivation: identification of a multigene domain in Xp11.21-p11.22 that escapes X inactivation.

Miller A, Willard H Proc Natl Acad Sci U S A. 1998; 95(15):8709-14.

PMID: 9671743 PMC: 21141. DOI: 10.1073/pnas.95.15.8709.

Linkage of genes for chronic granulomatous disease and Xg.

Wolff G, Muller C, Jobke A Hum Genet. 1980; 54(2):269-71.

PMID: 7390496 DOI: 10.1007/BF00278983.

X chromosome constitution and the human female phenotype.

THERMAN E, Denniston C, Sarto G, Ulber M Hum Genet. 1980; 54(2):133-43.

PMID: 7390488 DOI: 10.1007/BF00278961.

Failure of X inactivation in the autosomal segment of an X/A translocation.

Palmer C, Hubbard T, Henry G, Weaver D Am J Hum Genet. 1980; 32(2):179-87.

PMID: 7386454 PMC: 1686009.

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