Virulence Evolution in a Virus Obeys a Trade-off

Overview

Journal Proc Biol Sci

Specialty Biology

Date 1999 Mar 31

PMID 10097397

Citations 70

Authors

S L Messenger

I J Molineux

J J Bull

Affiliations

Soon will be listed here.

Abstract

The evolution of virulence was studied in a virus subjected to alternating episodes of vertical and horizontal transmission. Bacteriophage f1 was used as the parasite because it establishes a debilitating but non-fatal infection that can be transmitted vertically (from a host to its progeny) as well as horizontally (infection of new hosts). Horizontal transmission was required of all phage at specific intervals, but was prevented otherwise. Each episode of horizontal transmission was followed by an interval of obligate vertical transmission, followed by an interval of obligate horizontal transmission etc. The duration of vertical transmission was eight times longer per episode in one treatment than in the other, thus varying the relative intensity of selection against virulence while maintaining selection for some level of virus production. Viral lines with the higher enforced rate of infectious transmission evolved higher virulence and higher rates of virus production. These results support the trade-off model for the evolution of virulence.

Citing Articles

The evolutionary cost of homophily: Social stratification facilitates stable variant coexistence and increased rates of evolution in host-associated pathogens.

Li S, Gulisija D, Carja O PLoS Comput Biol. 2024; 20(11):e1012619.

PMID: 39576842 PMC: 11623455. DOI: 10.1371/journal.pcbi.1012619.

Multispecies interactions and the community context of the evolution of virulence.

Evensen C, White A, Boots M Proc Biol Sci. 2024; 291(2031):20240991.

PMID: 39317313 PMC: 11421928. DOI: 10.1098/rspb.2024.0991.

The evolutionary cost of homophily: social stratification facilitates stable variant coexistence and increased rates of evolution in host-associated pathogens.

Li S, Gulisija D, Carja O bioRxiv. 2024; .

PMID: 39071438 PMC: 11275799. DOI: 10.1101/2024.07.14.603415.

Emerging evidence of seed transmission of begomoviruses: implications in global circulation and disease outbreak.

Sandra N, Mandal B Front Plant Sci. 2024; 15:1376284.

PMID: 38807782 PMC: 11130427. DOI: 10.3389/fpls.2024.1376284.

Death is overrated: the potential role of detection in driving virulence evolution.

Kennedy D Proc Biol Sci. 2023; 290(1995):20230117.

PMID: 36987649 PMC: 10050922. DOI: 10.1098/rspb.2023.0117.

References

Lerner T, Model P . The "steady state" of coliphage f1: DNA synthesis late in infection. Virology. 1981; 115(2):282-94. DOI: 10.1016/0042-6822(81)90111-2. View

Marvin D, Hohn B . Filamentous bacterial viruses. Bacteriol Rev. 1969; 33(2):172-209. PMC: 378320. DOI: 10.1128/br.33.2.172-209.1969. View

May R, Anderson R . Epidemiology and genetics in the coevolution of parasites and hosts. Proc R Soc Lond B Biol Sci. 1983; 219(1216):281-313. DOI: 10.1098/rspb.1983.0075. View

Diffley P, Scott J, Mama K, Tsen T . The rate of proliferation among African trypanosomes is a stable trait that is directly related to virulence. Am J Trop Med Hyg. 1987; 36(3):533-40. DOI: 10.4269/ajtmh.1987.36.533. View

Frank S . Models of parasite virulence. Q Rev Biol. 1996; 71(1):37-78. DOI: 10.1086/419267. View

Ebert D . Virulence and local adaptation of a horizontally transmitted parasite. Science. 1994; 265(5175):1084-6. DOI: 10.1126/science.265.5175.1084. View

Dearsly A, Sinden R, Self I . Sexual development in malarial parasites: gametocyte production, fertility and infectivity to the mosquito vector. Parasitology. 1990; 100 Pt 3:359-68. DOI: 10.1017/s0031182000078628. View

Ewald P . Guarding against the most dangerous emerging pathogens. Emerg Infect Dis. 1996; 2(4):245-57. PMC: 2639916. DOI: 10.3201/eid0204.960401. View

Terwilliger T, Fulford W, Zabin H . A genetic selection for temperature-sensitive variants of the gene V protein of bacteriophage f1. Nucleic Acids Res. 1988; 16(18):9027-39. PMC: 338650. DOI: 10.1093/nar/16.18.9027. View

10.

Anderson R, May R . Coevolution of hosts and parasites. Parasitology. 1982; 85 (Pt 2):411-26. DOI: 10.1017/s0031182000055360. View

11.

Levin B, Svanborg Eden C . Selection and evolution of virulence in bacteria: an ecumenical excursion and modest suggestion. Parasitology. 1990; 100 Suppl:S103-15. DOI: 10.1017/s0031182000073054. View

12.

Ferretti J, Gilmore K, Courvalin P . Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two.... J Bacteriol. 1986; 167(2):631-8. PMC: 212936. DOI: 10.1128/jb.167.2.631-638.1986. View

13.

Frank S . A kin selection model for the evolution of virulence. Proc Biol Sci. 1992; 250(1329):195-7. DOI: 10.1098/rspb.1992.0149. View

14.

Kim M, Hines J, Ray D . Viable deletions of the M13 complementary strand origin. Proc Natl Acad Sci U S A. 1981; 78(11):6784-8. PMC: 349135. DOI: 10.1073/pnas.78.11.6784. View

15.

Herre E . Population structure and the evolution of virulence in nematode parasites of fig wasps. Science. 1993; 259(5100):1442-5. DOI: 10.1126/science.259.5100.1442. View

16.

Ewald P . Transmission modes and evolution of the parasitism-mutualism continuum. Ann N Y Acad Sci. 1987; 503:295-306. DOI: 10.1111/j.1749-6632.1987.tb40616.x. View