Stimulation of Sodium and Water Secretion Without Inhibition of Glucose Absorption in the Rat Jejunum by Vasoactive Intestinal Peptide (VIP)

1. Infusion of vasoactive intestinal peptide (VIP) into the arterial blood supply of the small intestine in anesthetized rats did not alter either the perfusion pressure in the superior mesenteric artery or the active absorption of glucose from the jejunum, but did produce a large net secretion of Na+ and water into the lumen of the jejunum. 2. The results are compared to the effects of prostaglandin E1 which stimulates Na+ and water secretion and inhibits glucose active absorption in the rat jejunum.