Influenza Vaccination in Liver Transplant Recipients

Overview

Journal Transplantation

Specialty General Surgery

Date 1999 Mar 30

PMID 10096534

Citations 14

Authors

G Burbach

U Bienzle

K Stark

N Rayes

R Neuhaus

S Serke

H Engelmann

W Kunzel

G Turk

P Neuhaus

Affiliations

Soon will be listed here.

Abstract

Background: The immunogenicity of the trivalent inactivated influenza split virus vaccine (Infusplit SSW 97/98) containing A/Bayern/07/95 (H1N1)-like (A/Johannesburg/82/96 [NIB-39]), A/Wuhan/359/95 (H3N2)-like (A/Nanchang/933/95 [Resvir-0]), and B/Beijing/184/93-like (B/Harbin/7/94) hemagglutinin antigens was tested in liver transplant recipients (TXL-R).

Subjects And Methods: Serum antibody titers were determined 21+/-2 days after a single vaccination in 62 adult TXL-R and 59 adult volunteers.

Results: Protective postimmunization antibody titers for the three antigens were similar in TXL-R (protection rates 92%, 92%, and 95%) and the comparison group (97%, 100%, and 100%). Adverse reactions were mild and less frequent in TXL-R. A significant decrease of CD8+CD38+ lymphocytes after vaccination was found in TXL-R. No association between antibody response and age, gender, time interval since transplantation, anti-hepatitis B surface antigen immunoprophylaxis, or immunosuppressive medication was detected.

Conclusion: Our results show that the vaccine is safe and effective and should be recommended to TXL-R.

Citing Articles

Vaccine Responses in Patients with Liver Cirrhosis: From the Immune System to the Gut Microbiota.

Airola C, Andaloro S, Gasbarrini A, Ponziani F Vaccines (Basel). 2024; 12(4).

PMID: 38675732 PMC: 11054513. DOI: 10.3390/vaccines12040349.

Vaccination in liver diseases and liver Transplantation: Recommendations, implications and opportunities in the post-covid era.

Ballester M, Jalan R, Mehta G JHEP Rep. 2023; :100776.

PMID: 37360567 PMC: 10241163. DOI: 10.1016/j.jhepr.2023.100776.

Optimizing Immunization Strategies in Adult Patients With Chronic Liver Disease and Liver Transplant Recipients.

Rolak S, Said A, German R, Hayney M, Caldera F Gastroenterol Hepatol (N Y). 2022; 18(4):196-206.

PMID: 35505940 PMC: 9053492.

Effect of the adjuvanted (AS03) A/H1N1 2009 pandemic influenza vaccine on the risk of rejection in solid organ transplant recipients in England: a self-controlled case series.

Cohet C, Haguinet F, Dos Santos G, Webb D, Logie J, Lc Ferreira G BMJ Open. 2016; 6(1):e009264.

PMID: 26823177 PMC: 4735133. DOI: 10.1136/bmjopen-2015-009264.

Prevention and Management of Chronic Hepatitis B.

Bhat M, Ghali P, Deschenes M, Wong P Int J Prev Med. 2015; 5(Suppl 3):S200-7.

PMID: 26622990 PMC: 4635410.