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Bi-cycling the Furin Pathway: from TGN Localization to Pathogen Activation and Embryogenesis

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Specialty Cell Biology
Date 1999 Mar 24
PMID 10087614
Citations 141
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Abstract

Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to pathogen proteins, in multiple compartments within the trans-Golgi network (TGN)/endosomal system. This review focuses on recent developments in the biochemistry and cell biology of the endoprotease, including the mechanism of TGN localization, phosphorylation-dependent regulation of protein traffic, and novel insights into early embryogenesis, extracellular matrix formation and pathogen virulence.

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