Iron Chelator Deferoxamine Reduces Preneoplastic Lesions in Liver Induced by Choline-deficient L-amino Acid-defined Diet in Rats

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1999 Mar 18

PMID 10080151

Citations 13

Authors

I Sakaida

K Hironaka

K Uchida

K Okita

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate whether an iron chelator, deferoxamine (DFO) can prevent lipid peroxidation, resulting in reduced liver injury as well as reducing preneoplastic lesions induced by a choline-deficient L-amino acid-defined (CDAA) diet. CDAA diet administration resulted in an increased serum ALT level (367 +/- 58) after two weeks, but simultaneous DFO treatment for two weeks reduced this elevation of ALT as well as malondialdehyde (MDA) production in the liver. Feeding rats a CDAA diet for 12 weeks led to the development of severe liver fibrosis and preneoplastic lesions detected as enzyme-altered lesions. DFO treatment prevented the expression of activated stellate cells, resulting in the reduction of liver fibrosis as well as reducing the development of preneoplastic lesions. These results indicate that iron chelation can reduce the development of preneoplastic lesions in a CDAA diet model.

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