Infidelity of DNA Synthesis in Vitro: Screening for Potential Metal Mutagens or Carcinogens

Overview

Journal Science

Specialty Science

Date 1976 Dec 24

PMID 1006310

Citations 68

Authors

M A Sirover

L A Loeb

Affiliations

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Abstract

Thirty-one metal salts have been tested for their ability to affect the accuracy of DNA synthesis in vitro. All ten salts of metal carcinogens decreased the fidelity of DNA synthesis. Of the three metals which beforehand were considered to be possible mutagens or carcinogens, only one decreased fidelity. In contrast, 17 noncarcinogenic metal salts did not affect fidelity even when present at concentrations that were clearly inhibitory.

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