The Hamster As an Experimental Animal for the Study of Influenza. II. The Role of Spleen Cells in Protection

Overview

Journal Med Microbiol Immunol

Specialty Allergy & Immunology

Date 1976 Dec 1

PMID 1004376

Citations 8

Authors

R Jennings

J P Phair

M D Denton

C W POTTER

Affiliations

Soon will be listed here.

Abstract

Hamsters previously infected by influenza viruses, have been shown to have a cell-mediated immune response, as measured by the macrophage migration inhibition test. The participation of spleen cells in the protection of recipients against homologous influenza virus infection was also demonstrated using adoptive transfer experiments. However, the protection achieved by spleen cell transfer was marginal and not observed in every animal. The time at which the spleen cells were transferred following infection, and their number, affected the outcome. Evidence suggesting that transferred spleen cells protected recipient hamsters through specific antibody is presented.

Citing Articles

Syrian Hamster as an Animal Model for the Study of Human Influenza Virus Infection.

Iwatsuki-Horimoto K, Nakajima N, Ichiko Y, Sakai-Tagawa Y, Noda T, Hasegawa H J Virol. 2017; 92(4).

PMID: 29212926 PMC: 5790951. DOI: 10.1128/JVI.01693-17.

Animal models for influenza viruses: implications for universal vaccine development.

Margine I, Krammer F Pathogens. 2014; 3(4):845-74.

PMID: 25436508 PMC: 4282889. DOI: 10.3390/pathogens3040845.

Metabolism of amino acids differs in the brains of Djungarian hamster (P. sungorus) and Roborovskii hamster (P. roborovskii).

Ikeda H, Kawase T, Nagasawa M, Chowdhury V, Yasuo S, Furuse M Springerplus. 2014; 3:277.

PMID: 24936396 PMC: 4057556. DOI: 10.1186/2193-1801-3-277.

The hamster as an experimental animal for the study of influenza. I. The role of antibody in protection.

Jennings R, Denton M, POTTER C Med Microbiol Immunol. 1976; 162(3-4):217-26.

PMID: 1004375 DOI: 10.1007/BF02121000.

A contribution of cellular immunity to protection against influenza in man.

Jennings R, Fenton R, McENTEGART M, POTTER C Med Microbiol Immunol. 1978; 166(1-4):51-62.

PMID: 723791 DOI: 10.1007/BF02121134.

References

Ruckdeschel J, Graziano K, MARDINEY Jr M . Additional evidence that the cell-associated immune system is the primary host defense against measles (rubeola). Cell Immunol. 1975; 17(1):11-8. DOI: 10.1016/s0008-8749(75)80002-5. View

Kurimura T, Hirano A . Cross immune reactions between A(H1N1) and A(H2N2) influenza viruses. Biken J. 1973; 16(2):51-6. View

Hirsch M, Murphy F . Effects of anti-lymphoid sera on viral infections. Lancet. 1968; 2(7558):37-40. DOI: 10.1016/s0140-6736(68)92904-8. View

Suzuki F, Oya J, Ishida N . Effect of antilymphocyte serum on influenza virus infection in mice. Proc Soc Exp Biol Med. 1974; 146(1):78-84. DOI: 10.3181/00379727-146-38047. View

POTTER C, Jennings R, Rees R, McLaren C . Antibody response of hamsters to A2-Hong Kong virus vaccine after priming by heterotypic virus infection. Infect Immun. 1973; 8(2):137-44. PMC: 422824. DOI: 10.1128/iai.8.2.137-144.1973. View

Feinstone S, Beachey E, RYTEL M . Induction of delayed hypersensitivity to influenza and mumps viruses in mice. J Immunol. 1969; 103(4):844-9. View

Rees R, POTTER C . Immune response to adenovirus 12-induced tumour antigens, as measured in vitro by the macrophage migration inhibition test. Eur J Cancer (1965). 1973; 9(7):497-502. DOI: 10.1016/0014-2964(73)90134-5. View

Blanden R . Mechanisms of recovery from a generalized viral infection: mousepox. II. Passive transfer of recovery mechanisms with immune lymphoid cells. J Exp Med. 1971; 133(5):1074-89. PMC: 2138917. DOI: 10.1084/jem.133.5.1074. View

FREESTONE D, Schild G, Buckland R, Chinn S, Tyrrell D . Antibody responses and resistance to challenge in volunteers vaccinated with live attenuated, detergent split and oil adjuvant A2-Hong Kong-68 (H 3 N 2 ) influenza vaccines. A report to the Medical Research Council Committee on Influenza and other.... J Hyg (Lond). 1972; 70(3):531-43. PMC: 2130202. DOI: 10.1017/s0022172400063117. View

10.

Rager-Zisman B, Allison A . The role of antibody and host cells in the resistance of mice against infection by coxsackie B-3 virus. J Gen Virol. 1973; 19(3):329-38. DOI: 10.1099/0022-1317-19-3-329. View

11.

FRENKEL J, Wilson H . Effects of radiation on specific cellular immunities: besnoitiosis and a herpesvirus infection of hamsters. J Infect Dis. 1972; 125(3):216-30. DOI: 10.1093/infdis/125.3.216. View

12.

Ennis F, RUTH W, Wells M . Host defense mechanisms against infection with influenza virus. I. Effect of sensitized spleen cells on infection in vitro. J Infect Dis. 1974; 130(3):248-56. DOI: 10.1093/infdis/130.3.248. View

13.

Glasgow L . Cellular immunity in host resistance to viral infections. Arch Intern Med. 1970; 126(1):125-34. View

14.

Cambridge G, MacKenzie J, Keast D . Cell-mediated immune response to influenza virus infections in mice. Infect Immun. 1976; 13(1):36-43. PMC: 420574. DOI: 10.1128/iai.13.1.36-43.1976. View

15.

Fernald G, METZGAR R . In vitro studies of the response of hamster lymphocytes to phytohemagglutinin and antigenic stimulation. J Immunol. 1971; 107(2):456-63. View

16.

Habershon R, Molyneux M, Slavin G, LOEWI G, Tyrrell D . Skin tests with influenza virus. J Hyg (Lond). 1973; 71(4):755-60. PMC: 2130428. DOI: 10.1017/s0022172400023019. View

17.

Jennings R, Denton M, POTTER C . The hamster as an experimental animal for the study of influenza. I. The role of antibody in protection. Med Microbiol Immunol. 1976; 162(3-4):217-26. DOI: 10.1007/BF02121000. View

18.

David J, AL-ASKARI S, LAWRENCE H, Thomas L . DELAYED HYPERSENSITIVITY IN VITRO. I. THE SPECIFICITY OF INHIBITION OF CELL MIGRATION BY ANTIGENS. J Immunol. 1964; 93:264-73. View

19.

Hobson D, CURRY R, Beare A . The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses. J Hyg (Lond). 1972; 70(4):767-77. PMC: 2130285. DOI: 10.1017/s0022172400022610. View

20.

Merigan T . Host defenses against viral disease. N Engl J Med. 1974; 290(6):323-9. DOI: 10.1056/NEJM197402072900608. View